Simulation Packages Expand Aircraft Design Options

NASA Technology

When engineers explore designs for safer, more fuel efficient, or faster aircraft, they encounter a common problem: they never know exactly what will happen until the vehicle gets off the ground.

“You will never get the complete answer until you build the airplane and fly it,” says Colin Johnson of Desktop Aeronautics. “There are multiple levels of simulation you can do to approximate the vehicle’s performance, however.”

altWhen designing a new air vehicle, computational fluid dynamics, or CFD, comes in very handy for engineers. CFD can predict the flow of fluids and gasses around an object—such as over an aircraft’s wing—by running complex calculations of the fluid physics. This information is helpful in assessing the aircraft’s aerodynamic performance and handling characteristics.

In 2001, after several years of development, NASA released a new approach to CFD called Cart3D. The tool provides designers with an automated, highly accurate computer simulation suite to streamline the conceptual analysis of aerospace vehicles. Specifically, it allows users to perform automated CFD analysis on complex vehicle designs. In 2002, the innovation won NASA’s Software of the Year award.

Michael Aftosmis, one of the developers of Cart3D and a fluid mechanics engineer at Ames Research Center, says the main purpose of the program was to remove the mesh generation bottleneck from CFD. A major benefit of Cart3D is that the mesh, or the grid for analyzing designs, is produced automatically. Traditionally, the mesh has been generated by hand, and requires months or years to produce for complex vehicle configurations. Cart3D’s automated volume mesh generation enables even the most complex geometries to be modeled hundreds of times faster, usually within seconds. “It allows a novice user to get the same quality results as an expert,” says Aftosmis.

Now, a decade later, NASA continues to enhance Cart3D to meet users’ needs for speed, power, and flexibility. Cart3D provides the best of both worlds—the payoff of using a complex, high-fidelity simulation with the ease of use and speed of a much simpler, lower-fidelity simulation method. Aftosmis explains how instead of simulating just one case, Cart3D’s ease of use and automation allows a user to efficiently simulate many cases to understand how a vehicle behaves for a range of conditions. “Cart3D is the first tool that was able to do that successfully,” he says.

At NASA, Aftosmis estimates that 300–400 engineers use the package. “We use it for space vehicle design, supersonic aircraft design, and subsonic aircraft design.”

Technology Transfer

To enable more use of Cart3D for private and commercial aviation entities, the Small Business Innovation Research (SBIR) program at Langley Research Center provided funds to Desktop Aeronautics, based in Palo Alto, California, to build a plug-in to Cart3D that increases the code’s accuracy under particular flow conditions. Aftosmis says Desktop Aeronautics delivered valuable results and made Cart3D more applicable for general use. “Now they are bringing the product to market. This is something we never would have had the time to do at NASA. That’s the way the SBIR process is supposed to work.”

In 2010, Desktop Aeronautics acquired a license from Ames to sell Cart3D. The company further enhanced the software by making it cross-platform, incorporated a graphical user interface, and added specialized features to enable extra computation for the analysis of airplanes with engines and exhaust.

“I think it’s going to be game-changing for CFD,” says Aftosmis. “Cart3D is the only commercial simulation tool that can guarantee the accuracy of every solution the user does.”


Benefits

altToday, Desktop Aeronautics employs Cart3D in its consulting services and licenses the spinoff product to clients for in-house use. The company provides commercial licenses and academic licenses for research and development projects.

The software package allows users to perform automated CFD analysis on complex designs and, according to the company, enables geometry acquisition and mesh generation to be performed within a few minutes on most desktop computers.

Simulations generated by Cart3D are assisting organizations in the design of subsonic aircraft, space planes, spacecraft, and high speed commercial jets. Customers are able to simulate the efficiency of designs through performance metrics such as lift-to-drag ratio.

“It will assemble a spectrum of solutions for many different cases, and from that spectrum, the cases that perform best give insight into how to improve one’s design,” says Johnson. “Cart3D’s preeminent benefit is that it’s automated and can handle complex geometry. It’s blazing fast. You push a button, and it takes care of the volume meshing and flow measurement.”

Without building an aircraft, engineers can never be completely certain which design concept will perform best in flight. However, they now have a tool to make the most informed prediction possible.

[Source]

Advertisements

The Center for the Advancement of Science in Space is increasingly green-lighting research projects for the International Space Station.

The crystals on the left were grown in microgravity. Those on the right formed on Earth.  (NASA)

Get ready for the rodents in outer space to outnumber the humans. The Center for the Advancement of Science in Space is increasingly green-lighting research projects for the International Space Station.

The organization expects that the unique conditions of outer space could lead to research breakthroughs.

“We believe there are scientific projects that people haven’t even thought about taking gravity out of the equation, and if they realize how easy it is and how accessible it is to get to the space station they’d be all over it,” said Greg Johnson, the executive director of the Center for the Advancement of Science in Space.

The organization approved 28 projects in 2013 and expects to launch more this year. In 2011 it began managing the U.S. lab on the International Space Station for NASA.

“There are things we can learn about the planet from 250 miles we frankly just can’t learn from here,” Johnson said. “We can learn about algal blooms in oceans. We can better understand patterns in the atmosphere and how they interface with land masses and water masses.”

In zero gravity, human and animal bones degenerate, opening a door for studying osteoporosis. Prolia, a drug designed to treat postmenopausal osteoporosis, was developed using research on lab rats that were tested on the space shuttle Endeavour in 2001.

One of the current experiments taking place on the International Space Station addresses Huntington’s disease, in which proteins clump up in a patient’s brain. The surface of the proteins mutate, making it hard for researchers to analyze them. Without an accurate depiction of the protein, scientists can’t design a drug to latch onto the surface and serve as a meaningful treatment for Huntington’s disease.

Gwen Owens, a Ph.D candidate at UCLA-Caltech, is studying the Huntington’s disease protein in crystal form. She heard an NPR segment about the Center for the Advancement of Science in Space and recalled a researcher’s work using micogravity. Given that crystals grow better in space, she figured it was worth pursuing.

“The real bottleneck is getting the crystals to form,” Owens said. “Once we have the crystals, it’s not that easy, but it’s not that hard.” Owens will get a better understanding of just how valuable zero gravity proves to be when her lab gets results back in September.

[Source]

Mars Cameras Make Panoramic Photography a Snap

Aside

Originating Technology/NASA Contribution

The Gigapan robotic platform holds a digital camera.
The Gigapan robotic platform now enables photographers on Earth to capture and create super-sized digital panoramas.

If you wish to explore a Martian landscape without leaving your armchair, a few simple clicks around the NASA Web site will lead you to panoramic photographs taken from the Mars Exploration Rovers, Spirit and Opportunity. Many of the technologies that enable this spectacular Mars photography have also inspired advancements in photography here on Earth, including the panoramic camera (Pancam) and its housing assembly, designed by the Jet Propulsion Laboratory and Cornell University for the Mars missions. Mounted atop each rover, the Pancam mast assembly (PMA) can tilt a full 180 degrees and swivel 360 degrees, allowing for a complete, highly detailed view of the Martian landscape.

The rover Pancams take small, 1 megapixel (1 million pixel) digital photographs, which are stitched together into large panoramas that sometimes measure 4 by 24 megapixels. The Pancam software performs some image correction and stitching after the photographs are transmitted back to Earth. Different lens filters and a spectrometer also assist scientists in their analyses of infrared radiation from the objects in the photographs. These photographs from Mars spurred developers to begin thinking in terms of larger and higher quality images: super-sized digital pictures, or gigapixels, which are images composed of 1 billion or more pixels.

Gigapixel images are more than 200 times the size captured by today’s standard 4 megapixel digital camera. Although originally created for the Mars missions, the detail provided by these large photographs allows for many purposes, not all of which are limited to extraterrestrial photography.

Partnership

The technology behind the Mars rover PMAs inspired Randy Sargent at Ames Research Center and Illah Nourbakhsh at Carnegie Mellon University (CMU) to look at ways consumers might be able to use similar technology for more “down-to-Earth” photography and virtual exploration.

In 2005, Sargent and Nourbakhsh created the Global Connection Project, a collaboration of scientists from CMU, Google Inc., and the National Geographic Society, whose vision is to encourage better understanding of the Earth’s cultures through images. This vision inspired the development of their Gigapan products.

After seeing what the Pancams and PMAs could do, Sargent created a prototype for a consumer-version of a robotic camera platform. He worked with Rich LeGrand of Charmed Labs LLC, in Austin, Texas, to design and manufacture the Gigapan robotic platform for standard digital cameras.

Product Outcome

The Gigapan robotic platform is, in essence, an intelligent tripod that enables an amateur photographer to set up detailed shots with ease. A user sets the upper-left and lower-right corners of the panorama, and the Gigapan simply will capture as many images as the user or scene requires. With this level of automation, a 500-picture panorama is no more complicated than a 4-picture panorama; only the camera’s memory limits the size of the panorama.

The Global Connection Project also created two other Gigapan products: a Gigapan Web site and panorama stitching software born from the Ames Vision Workbench, an image processing and computer vision library developed by the Autonomous Systems and Robotics Area in the Intelligent Systems Division.

A high-resolution composite photograph shows a monk atop a temple in Nepal, the temple at a distance, and a restaurant behind the temple.
Gigapan allows a photographer to capture extremely high-resolution panoramas, which a user can explore in depth. In this wide view of Boudhanath Stupa in Kathmandu, Nepal, it is possible to zoom all the way into the smallest, barely visible points in the picture, such as the monk standing on the roof of the temple or the sign above the Tibet Kitchen Restaurant and Bar.
Gigapan panoramic image courtesy of Jessee Mayfield.

The robotic platform works with the stitching software by precisely manipulating and aligning each shot ahead of time. The Gigapan software complements the robotic platform by arranging the parts of the panorama (potentially hundreds of individual photographs) into a grid where they are stitched together into a single, very large Gigapan image.

The Global Connection Project won a 2006 “Economic Development Award” from the Tech Museum Awards for its work in creating photographic overlays for Google Earth of areas affected by natural disasters. Government workers and concerned citizens used the images on Google Earth to see which areas needed help in the aftermath of Hurricane Katrina, Hurricane Rita, and the 2005 earthquake in Kashmir.

On the Gigapan Web site, a user can display a wide bird’s eye panorama and can then zoom in with impressive bug’s eye high-quality detail. On first impression, a panoramic photograph on Gigapan’s site might seem to be simply a wide-angle cityscape of a temple in Kathmandu. With each successive click, however, the user can zoom deeper and deeper into the photo, revealing more and more clear details: a monk hanging prayer flags on the roof of the temple and the Tibet Kitchen Restaurant and Bar a few blocks behind the temple, with a sign extolling passersby to taste their gourmet food.

As part of a continuing effort to connect people and cultures, the Global Connection Project encourages all users to upload their own panoramas from around the world on the Gigapan site. Users can explore such varied landscapes as a temple in Nepal, the Burning Man festival in the Nevada desert, a market in Guatemala, or the Boston skyline from the Charles River. Because of the much greater number of pixels, the resolution is unprecedented; the Gigapan software and robotic platforms can theoretically produce prints on 40-foot-wide paper without any loss in quality.

Whether or not photographers use the Gigapan mounts and software, anyone can upload their panoramas to the Gigapan Web site. Many users of Gigapan have uploaded standard panorama photographs, as well (although the site suggests photographs be at least 50 megabytes). This is just fine with the Gigapan and the Global Connection Project coordinators, whose aim is simply to encourage exploration and understanding of the various cultures in our world.

The Fine Family Foundation is sponsoring work with the Global Connection Project to enable botanists, geologists, archeologists, and other scientists around the world to document different aspects of the Earth’s cultures and ecosystems using Gigapan technology. Scientists are using Gigapan to document life in the upper redwood forest canopy in California, volcanoes in Hawaii, and glaciers in Norway.

There are also educational uses for the Gigapan: The Pennsylvania Board of Tourism uses Gigapan for Web site visitors wanting to explore Civil War sites virtually. Also, in collaboration with the United Nations Educational, Scientific and Cultural Organization (UNESCO), the Global Connection Project has distributed Gigapan to students in Pittsburgh, South Africa, and the Republic of Trinidad and Tobago, encouraging them to photograph their local culture and share those panoramas with the world. “The hope is that students will be able to have deeper connections to other cultures,” said Sargent.

A time-lapse Gigapan robotic mount is now in development, and a professional unit for larger SLR-style cameras may be released before the end of 2008.

Gigapan is a trademark of Carnegie Mellon University.

Boosting NASA’s Budget Will Help Fix Economy: Neil deGrasse Tyson

 

ItsNeil

 Reinvigorating space exploration in the United States will require not only boosting NASA’s budget but also getting the public to understand how pushing the boundaries of the space frontier benefits the country’s innovation, culture and economy, said renowned astronomer Neil deGrasse Tyson.

“Space is a $300 billion industry worldwide,” Tyson said. “NASA is a tiny percent of that. [But] that little bit is what inspires dreams.”

He spoke about how space has influenced culture — ranging from how the fins on early rockets inspired fins on automobiles in the 1950s, to how the Apollo 8 mission’s iconic picture taken in 1968 of Earth rising above the horizon of the moon led to a greater appreciation for our planet and the need to protect it. Yet, many people outside the space community see itas a special interest group, Tyson said.

“Innovation drives economy,” he said. “It’s especially been true since the Industrial Revolution.”

Tyson advocated doubling NASA’s budget — which President Barack Obama set at $17.7 billion in his 2013 federal budget request — and then laid out a different approach to space exploration that he called somewhat “unorthodox.” Rather than focusing on one destination at a time, Tyson promoted building a core fleet of launch vehicles that can be customized for a variety of missions and for a range of purposes.

“We’re kind of doing that now, but let’s do that as the focus,” Tyson said. “One configuration will get you to the moon. Another will get you to a Lagrangian point. Another will get you to Mars.”

Having an available suite of launch vehicles will open up access to space for a wider range of purposes, which will, in turn, benefit the country’s economy and innovation.

Tyson compared it with the country’s system of interstates, which helped connect cities across the country and made travel more efficient.

“When Eisenhower came back from Europe after he saw the [German] autobahn, and how it survived heavy climactic variation and troop maneuvers, he said, ‘I want some of that in my country,'” Tyson explained. “So he gets everyone to agree to build the interstate system. Did he say, ‘you know, I just want to build it from New York to L.A., because that’s where you should go?’ No. The interstate system connects everybody in whatever way you want. That’s how you grow a system.”

Furthermore, this type of capability can be used for a myriad of purposes, including military endeavors, science missions, commercial expeditions and space tourism.

“Whatever the needs or urges — be they geopolitical, military, economic — space becomes that frontier,” Tyson said. “Not only do you innovate, these innovations make headlines. Those headlines work their way down the educational pipeline. Everybody in school knows about it. You don’t have to set up a program to convince people that being an engineer is cool. They’ll know it just by the cultural presence of those activities. You do that, and it’ll jump-start our dreams.”

[Source]

Space Age Swimsuit Reduces Drag, Breaks Records

Originating Technology/NASA Contribution

An athlete swims toward the camera.
NASA helped Speedo reduce viscous drag in the new LZR Racer by performing surface drag testing and applying expertise in the area of fluid dynamics.

A space shuttle and a competitive swimmer have a lot more in common than people might realize: Among other forces, both have to contend with the slowing influence of drag. NASA’s Aeronautics Research Mission Directorate focuses primarily on improving flight efficiency and generally on fluid dynamics, especially the forces of pressure and viscous drag, which are the same for bodies moving through air as for bodies moving through water. Viscous drag is the force of friction that slows down a moving object through a substance, like air or water.

NASA uses wind tunnels for fluid dynamics research, studying the forces of friction in gasses and liquids. Pressure forces, according to Langley Research Center’s Stephen Wilkinson, “dictate the optimal shape and performance of an airplane or other aero/hydro-dynamic body.” In both high-speed flight and swimming, says Wilkinson, a thin boundary layer of reduced velocity fluid surrounds the moving body; this layer is about 2 centimeters thick for a swimmer.

Partnership

Key areas of compression in the LZR Racer swimsuit
The LZR Racer provides extra compression in key areas to help a swimmer use less energy to swim more quickly.

In spite of some initial skepticism, Los Angeles-based SpeedoUSA asked NASA to help design a swimsuit with reduced drag, shortly after the 2004 Olympics. According to Stuart Isaac, senior vice president of Team Sales and Sports Marketing, “People would look at us and say ‘this isn’t rocket science’ and we began to think, ‘well, actually, maybe it is.’” While most people would not associate space travel with swimwear, rocket science is exactly what SpeedoUSA decided to try. The manufacturer sought a partnership with NASA because of the Agency’s expertise in the field of fluid dynamics and in the area of combating drag.

A 2004 computational fluid dynamics study conducted by Speedo’s Aqualab research and development unit determined that the viscous drag on a swimmer is about 25 percent of the total retarding force. In competitive swimming, where every hundredth of a second counts, the best possible reduction in drag is crucially important. Researchers began flat plate testing of fabrics, using a small wind tunnel developed for earlier research on low-speed viscous drag reduction, and Wilkinson collaborated over the next few years with Speedo’s Aqualab to design what Speedo now considers the most efficient swimsuit yet: the LZR Racer. Surface drag testing was performed with the help of Langley, and additional water flume testing and computational fluid dynamics were performed with guidance from the University of Otago (New Zealand) and ANSYS Inc., a computer-aided engineering firm.

“Speedo had the materials in mind [for the LZR Racer],” explains Isaac, “but we did not know how they would perform in surface friction drag testing, which is where we enlisted the help of NASA.” The manufacturer says the fabric, which Speedo calls LZR Pulse, is not only efficient at reducing drag, but it also repels water and is extremely lightweight. Speedo tested about 100 materials and material coatings before settling on LZR Pulse.

NASA and Speedo performed tests on traditionally sewn seams, ultrasonically welded seams, and the fabric alone, which gave Speedo a baseline for reducing drag caused by seams and helped them identify problem areas. NASA wind tunnel results helped Speedo “create a bonding system that eliminates seams and reduces drag,” according to Isaac. The Speedo LZR Racer is the first fully bonded, full-body swimsuit with ultrasonically welded seams. Instead of sewing overlapping pieces of fabric together, Speedo actually fused the edges ultrasonically, reducing drag by 6 percent. “The ultrasonically welded seams have just slightly more drag than the fabric alone,” Isaac explains. NASA results also showed that a low-profile zipper ultrasonically bonded (not sewn) into the fabric and hidden inside the suit generated 8 percent less drag in wind tunnel tests than a standard zipper. Low-profile seams and zippers were a crucial component in the LZR Racer because the suit consists of multiple connecting fabric pieces—instead of just a few sewn pieces such as found in traditional suits—that provide extra compression for maximum efficiency.

Product Outcome

LZR Racer swimsuit covering the torso and legs of a swimmer

The LZR Racer reduces skin friction drag by covering more skin than traditional swimsuits. Multiple pieces of the water-resistant and extremely lightweight LZR Pulse fabric connect at ultrasonically welded seams and incorporate extremely low-profile zippers to keep viscous drag to a minimum. 

The LZR Racer reduces skin friction drag 24 percent more than the Fastskin, the previous Speedo racing suit fabric; and according to the manufacturer, the LZR Racer uses a Hydro Form Compression System to grip the body like a corset. Speedo experts say this compression helps the swimmers maintain the best form possible and enables them to swim longer and faster since they are using less energy to maintain form. The compression alone improves efficiency up to 5 percent, according to the manufacturer.

Olympic swimmer Katie Hoff, one of the American athletes wearing the suit in 2008 competitions, said that the tight suit helps a swimmer move more quickly through the water, because it “compresses [the] whole body so that [it’s] really streamlined.” Athletes from the French, Australian, and British Olympic teams all participated in testing the new Speedo racing suits.

Similar in style to a wetsuit, the LZR Racer can cover all or part of the legs, depending on personal preference and event. A swimmer can choose a full-body suit that covers the entire torso and extends to the ankles, or can opt for a suit with shorter legs above the knees. The more skin the LZR Racer covers, the more potential it has to reduce skin friction drag. The research seems to have paid off; in March 2008, athletes wearing the LZR Racer broke 13 world records.

Speedo®, LZR Pulse®, LZR Racer®, and FastSkin® are registered trademarks of Speedo Holdings B.V.

[Source]

NASA operating plan makes final adjustments for fiscal year 2014

NASA has released a summary of its fiscal year 2014 operating plan, which details any changes to spending for programs the agency has made (with the approval of Congress) from the final FY14 appropriations bill. As the table below shows, the changes are very minor; last year, NASA made bigger changes to adjust spending for agency priorities after the across-the-board cuts of sequestration went into effect. (The operating plan also provides a breakout of spending within Space Operations, which was omitted from the omnibus spending bill.)

All figures in Billions

Account FY14 Omnibus FY14 Ops Plan Difference
SCIENCE $5,151.20 $5,148.20 ($3.00)
– Earth Science $1,826.00 $1,824.90 ($1.10)
– Planetary Science $1,345.00 $1,343.40 ($1.60)
– Astrophysics $668.00 $678.30 $10.30
– JWST $658.20 $658.20 $0.00
– Heliophysics $654.00 $643.30 ($10.70)
SPACE TECHNOLOGY $576.00 $576.00 $0.00
AERONAUTICS $566.00 $566.00 $0.00
EXPLORATION SYSTEMS $4,113.20 $4,113.20 $0.00
– SLS/Orion $3,115.20 $3,115.20 $0.00
– Commercial Spaceflight $696.00 $696.00 $0.00
– Exploration R&D $302.0 $302.00 $0.00
SPACE OPERATIONS $3,778.00 $3,776.40 ($1.60)
– ISS n/a $2,964.10 NA
– Space and Flight Support n/a $812.30 NA
EDUCATION $116.60 $116.60 $0.00
CROSS AGENCY SUPPORT $2,793.00 $2,793.00 $0.00
CONSTRUCTION $515.00 $519.60 $4.60
INSPECTOR GENERAL $37.50 $37.50 $0.00
TOTAL $17,646.50 $17,646.50 ($3.10)

As SpacePolicyOnline.com (who requested the FY14 operating plan from NASA) notes, the operating plan still fully funds the SOFIA airborne observatory even though NASA is seeking to end funding for it in its FY15 budget proposal. However, there’s no guarantee that all of this funding would be used for operations of SOFIA: NASA officials warned in March that the $12 million proposed for FY15 might not be sufficient to cover the costs of mothballing the 747 aircraft
.

Circulation-Enhancing Device Improves CPR

Originating Technology/NASA Contribution

Ever stand up too quickly from a sitting or lying position and feel dizzy or disoriented for a brief moment? The downward push of Earth’s gravity naturally causes blood to settle in the lower areas of the human body, and occasionally, with a quick movement—such as rising swiftly from a chair—the body is not able to adjust fast enough to deliver an adequate supply of blood to the upper parts of the body and the brain. This sudden, temporary drop in blood pressure is what causes brief feelings of lightheadedness upon standing. In essence, when the heart pumps blood to different parts of the body, it is working against the physical phenomenon of gravity in its efforts to send blood up to the brain.

ResQPOD circulation-enhancing device
The ResQPOD is an impedance threshold device used to enhance circulation during CPR. It could be used to increase circulation for astronauts as their bodies initially adjust to a return to gravity from the weightlessness of space.

In more cases than not, the body is able to make the necessary adjustments to ensure proper blood flow and pressure to the brain; but when the disorientation lasts a long time and/or become chronic, individuals may have a condition called orthostatic intolerance. According to the American Journal of Physiology–Heart and Circulatory Physiology, an estimated 500,000 Americans are affected by orthostatic intolerance. Symptoms range from occasional fainting, blurry vision, and pain or discomfort in the head and the neck, to tiredness, weakness, and a lack of concentration. Though research indicates that the condition is not life-threatening, it could impact the quality of life and contribute to falls that result in serious injuries.

The condition is a prominent concern for NASA, since astronauts have to readjust to the gravitational environment of Earth after spending days in the weightlessness of space. NASA’s Exploration Systems Mission Directorate has found that roughly 20 percent of astronauts coming off of short-duration space flights experience difficulty maintaining proper blood pressure when moving from lying down to either sitting or standing during the first few days back on Earth. The difficulties are even more severe for astronauts coming off of long-duration missions, according to the mission directorate, as 83 percent of these crewmembers experience some degree of the condition.

Cardiovascular experts at NASA have found that the blood that normally settles in the lower regions of the body is instead pulled to the upper body in the microgravity environment of space. Blood volume is subsequently reduced as some cardiovascular reflexes are no longer being used, and less blood flows to the legs. Additionally, the muscles weaken, especially in the lower portion of the body, because they are not working (contracting) as hard as they usually do. This is not so much a concern for the astronauts while they are in space, since the action of floating around takes the place of putting center-of-gravity pressure on their legs. (They do exercise strenuously while in microgravity, though, to keep their muscles and circulatory systems conditioned, thus preparing their bodies for the return to gravity as best they can.) When they return to Earth’s gravity, however, more blood returns to the legs. Since there is a lower volume of blood, the flow that is supposed to be traveling to the brain can be insufficient. That is when orthostatic intolerance can set in.

NASA has conducted and sponsored a wealth of studies to counter the effects of orthostatic intolerance, especially since the condition could prevent an astronaut from exiting a landed spacecraft in the event of an emergency. In one study conducted by Johnson Space Center’s Cardiovascular Laboratory, astronauts in orbit tested the efficacy of a drug called midodrine that has successfully reduced orthostatic intolerance in patients on Earth. The early results were promising, but further testing will be conducted by the laboratory before more conclusive results can be determined. In another study, the laboratory is using a controlled tilt test on Earth to replicate the body’s responses to a shift from reclining to sitting or standing.

At Ames Research Center, researchers are utilizing NASA’s 20-G artificial gravity centrifuge machine in a pilot study on cardiovascular responses and fluid shifts in the body. A separate Ames study is evaluating the possibility of expanding astronauts’ plasma volumes (the fluid part of the blood, minus the blood cells), as a preventative measure.

Patient receiving respiratory support
The ResQPOD increases circulation in states of low blood pressure. When used on patients in cardiac arrest, the ResQPOD harnesses the chest wall recoil after each compression to generate a small but critical vacuum within the chest. This vacuum enhances blood flow back to the heart and results in a marked increase in blood flow out of the heart with each subsequent chest compression.

In NASA-sponsored research at Vanderbilt University, researchers have successfully identified a genetic cause for orthostatic intolerance. The findings marked the first time a genetic defect had been linked to a disorder of the autonomic immune system, according to the discoverers, and could eventually lead to new drugs and treatments for the condition.

At Kennedy Space Center, a collaborative research effort with the U.S. Army and private industry has yielded an important application for a new, non-invasive medical device called ResQPOD that is now available for astronauts returning from space. In helping to reacquaint the astronauts with the feeling of gravity, ResQPOD quickly and effectively increases the circulation of blood flow to the brain. This device is also available to the public as a means to enhance circulation for breathing patients suffering from orthostatic intolerance and for non-breathing patients suffering cardiac arrest or other high-risk clinical conditions attributed to low blood pressure.

Partnership

Advanced Circulatory Systems Inc., of Minneapolis, collaborated with Kennedy and the U.S. Army Institute of Surgical Research for more than 5 years to develop ResQPOD. Don Doerr, an engineer at Kennedy, led the testing and development effort; Dr. Victor Convertino of the Institute of Surgical Research (and a former NASA scientist at Kennedy) also played an instrumental role in developing the technology.

Multiple clinical studies were conducted during the research effort, including six published studies. The published works demonstrate that ResQPOD offers a significant improvement in cardiac output and blood flow to the brain and in preventing shock in the event of considerable blood loss, when compared to conventional resuscitation. According to Advanced Circulatory Systems, data from the NASA studies played a major role in the company obtaining U.S. Food and Drug Administration 501K clearance for the device.

Dr. Keith Lurie, chief medical officer at Advanced Circulatory Systems and a primary member of the collaborative research effort, said, “The three-way partnership between NASA, private industry, and the U.S. Army Institute of Surgical Research is really a model for how organizations can work together to benefit both government programs and civilians.”

In 2006, Dr. Smith Johnston, the lead flight surgeon for NASA’s space shuttle missions, added ResQPOD to the list of medical equipment that is available for returning astronaut crews. The device was on hand for the landing of Space Shuttle Atlantis (STS-115) on September 21, 2006.

“We’re excited that our devices were available to the medical team [for the STS-115 mission] and look forward to continued collaboration with NASA to assist its efforts to safeguard the health of the astronauts,” added Lurie.

Diagram showing blood flow to the heart during CPR
During the decompression (release) phase of CPR, an increase in negative pressure in the thoracic cavity results in drawing more blood back into the chest, providing greater venous return to the heart.
Diagram showing increased blood flow to the heart with ResQPOD
CPR delivers approximately 15 percent of normal blood flow to the heart. The ResQPOD doubles blood flow back to the heart.

Product Outcome

Manufactured commercially by Advanced Circulatory Systems and distributed by Sylmar, California-based Tri-anim Health Services Inc., the ResQPOD circulatory enhancer improves upon the standard of care for patients with a variety of clinical conditions associated with low blood flow. Advanced Circulatory Systems’ primary commercial focus, though, is on non-breathing patients who can benefit from enhanced circulation, such as those experiencing cardiac arrest.

According to the American Heart Association, about 900 Americans fall victim to sudden cardiac arrest every day, with approximately 95 percent dying before they reach the hospital. This is why cardiopulmonary resuscitation (CPR) can mean the difference between life and death, as increasing blood flow to the heart and brain until the heart can be restarted is critical to improving survival rates with normal neurological functioning.

ResQPOD is an American Heart Association-rated Class IIa impedance threshold device, meaning that it is the highest recommended “adjunct” in the association’s latest guidelines for CPR. As a Class IIa impedance threshold device, it also carries a higher recommendation than any medication used to boost circulation in adults suffering cardiac arrest, according to these guidelines.

Diagram showing blood flow to the brain during CPR
Improved venous return results in increased cardiac output during the subsequent compression phase of CPR, providing greater blood flow to the brain.
Diagram showing increased blood flow to the brain with ResQPOD
CPR delivers approximately 25 percent of normal blood flow to the brain. The ResQPOD delivers more than 70 percent of normal blood flow to the brain.

The device is about the size of a fist and can be affixed to either a facemask or an endotracheal breathing tube during CPR. It enhances the intrathoracic vacuum that forms in the chest during the chest recoil phase of CPR by temporarily sealing off the airway between breaths and preventing unnecessary air from entering the chest (timing-assist lights on the device will aid the rescuer in ventilating the patient at a proper rate). The vacuum that is created pulls blood back to the heart, doubling the amount of blood that is pulled back by conventional mouth-to-mouth/chest compression CPR, according to clinical studies, which also show that blood flow to the brain is increased by 50 percent. In sustaining proper blood flow to the heart and to the brain, ResQPOD increases the likelihood of survival and decreases the likelihood of neurological disorders.

ResQPOD is being used by emergency medical technicians in cities all around the country, including Boston, Houston, Indianapolis, Miami, and Oklahoma City, as well as Hartford, Connecticut; Kansas City, Missouri; Raleigh, North Carolina; and Toledo, Ohio. In some cities, it has reportedly increased the number of cardiac arrest patients delivered alive to the hospital by as much as 50 percent. At Cypress Creek Emergency Medical Services (EMS), a large medical care organization serving more than 400,000 residents in the greater Houston area, ResQPOD has become a standard of care. Overall resuscitation rates climbed to nearly 50 percent since the organization began deploying the device in 2005, boosting hospital admission rates from 26 percent to an astounding 38 percent.

“These results are gratifying, and we applaud the entire Cypress Creek EMS organization for their advanced emergency medical service care and their ability to turn around the dismal statistics that surround cardiac arrest,” noted Advanced Circulatory Systems’ Lurie.

In its secondary commercial applications, Advanced Circulatory Systems is offering ResQPOD to improve circulation in patients suffering from orthostatic intolerance and general low blood pressure. These secondary uses also apply to individuals who undergo dialysis treatments and may experience a drop in blood pressure, as well as those who go into shock after severe blood loss.

Outside of the traditional hospital setting, the company is investigating the beneficial impact ResQPOD could have on wounded soldiers in the battlefield who may have lost a great deal of blood and are in danger of going into shock.

Advanced Circulatory Systems is also harnessing the physiological principles discovered during its research collaboration with NASA to develop another promising technology: an intrathoracic pressure regulator for patients requiring ventilation assistance because they are too sick to breathe on their own.

ResQPOD® is a registered trademark of Advanced Circulatory Systems Inc.

[Source]